In 80 AD Emperor Titus opens the Colosseum with 100 days of spectacular games, including one of the most famous gladiatorial matches in Rome's history.

By the 4th Century AD, a divided Roman Empire is rocked by devastating earthquakes, fires, barbarian invasions and deep religious divides. As Rome declines, the Colosseum, which once stood as a proud symbol of the Empire's glory, lies empty.

One of the most famous doctor/scientists of the ancient world, Galen of Pergamon makes a name for himself as a physician for gladiators in the arena.

As the Roman Empire continues to expand, so does the diversity of exotic beasts brought back to entertain the Colosseum crowds. Over a million animals are slaughtered on the sands of the arena by trained beast masters, none more famous than Carpophorus.