The saga of El Mariachi continues when a corrupt CIA agent forces him out of hiding to help sabotage an assassination attempt on the president of Mexico by an evil cartel kingpin. El Mariachi has his own reason for helping - he is doing it for revenge.

Forensic psychologist Dr. Samatha "Sam" Waters has an uncanny ability to use clues left at crime scenes to "see" what happened. She is one of the FBI's most valuabel assests. She retreats into a self-imposed exile after the murder of her husband. Coaxed back to the Bureau by her mentor, Sam picks up where she left off to help unravel high-profile cases that stymie other investigators.

Just trying to find a legitimate job, a bad boy trying to make good, has the golden crime of a lifetime litterally fall into his hands. Now both the mob and the Feds are after him. Along the way he meets a beautiful woman whose father is somehow involved.