A mildly autistic man and a dancer form a friendship that helps them better understand the world that appears to have left them both behind. After crossing paths seemingly by chance, Noah and Alexia take a journey that forces them both out of their comfort zones and challenges their perceptions of love.

The show is about a young surgeon with autism who is recruited to work at a pediatric unit of a hospital. The hospital is prestigious with many of the toughest cases a surgeon could ever see, but with autism comes clarity that most surgeons will never have. The television series focuses on the relationship between the doctor and patient, and how a man who cannot relate to the people who he tries to help.

Shaun's proposed treatment for a homeless patient puts him and Jared in Andrews' crosshairs. Meanwhile, Claire tries to overcome Melendez' reluctance to do a risky heart operation while Glassman must overcome his personal feelings about his oncologist, Dr. Marina Blaize, and face a difficult decision about his health.