Nelville Flynn is escorting a witness on a plane that is bound for Los Angeles. The problem is that an assassin is bent on killing the witness. The assassin releases a crate containing about 450 deadly snakes onto the same plane. Nelville finds out and he becomes bent on doing his job and getting the snakes back where they belong - on land. If the snakes won't cooperate with Nelville, he will just have to send the snakes on to snake heaven.

Dusty is a cropdusting plane with dreams of competing as a high-flying air racer. But Dusty's not exactly built for racing, and he happens to be afraid of heights. So he turns to a seasoned naval aviator, who helps Dusty qualify to take on the defending champ of the race circuit. Dusty's courage is put to the ultimate test.

The passengers and crew on an international flight become involved in a mid-flight emergency after authorities discover that a suspect involved with a terroristic threat boarded the plane and a healthy passenger suddenly becomes severely ill and dies.